Denosumab (anti-RANK ligand)

Product Name： Denosumab biosimilar

CAS No.:   615258-40-7                               

Formula:    C₆₄₀₄H₉₉₁₂N₁₇₂₄O₂₀₀₄S₅₀                         

Molecular Weight：  147 kDa                

Type:     Whole antibody                   

Target：  RANK ligand
Antibody Form:  Purified immunoglobulin  
Physical Form:   Solution
Storage:  -70±15℃ for long-term storage, 2-8℃ for short-term storage, away from light.

Description

Denosumab biosimilar is a human IgG2 monoclonal antibody that binds to human RANKL. Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.

Biological Activity
Denosumab (anti-RANK ligand) (AMG-162, Prolia, Xgeva) is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL (143–317) to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM.

For research use only. Not for use in humans